For Gonzalez, the idea of working harder than anyone else was instilled at an early age, but the benefits of setting a routine became apparent in his second season with the Chiefs. Facing high expectations after moving into the starting lineup, he dropped 17 passes. He knew something had to change, so he started reading books on other great athletes, from Rice to Michael Jordan..Transactivation response (TAR) DNAbinding protein of 43 kDa (TDP43) encoded by the TARDBP gene on chromosome 1 is a major component of and ubiquitinpositive inclusions that characterize amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) linked to TDP43 pathology (FTLDTDP) (Neumann et al, 2006). Recent studies have identified TDP43 aggregation and neuropathology in a wide spectrum of distinct neurodegenerative disorders collectively known as TDP43 proteinopathies, supporting a central role for TDP43 in neurodegenerative disease pathogenesis (Pesiridis et al, 2009; LagierTourenne